A question of library design

Philip J. Hajduk, Warren R. J. D. Galloway and David R. Spring
Additional contact information
Philip J. Hajduk: Abbott Laboratories, Abbott Park, Illinois 60064, USA. philip.hajduk@abbott.com
Warren R. J. D. Galloway: University of Cambridge, Cambridge CB2 1EW, UK. spring@ch.cam.ac.uk
David R. Spring: University of Cambridge, Cambridge CB2 1EW, UK. spring@ch.cam.ac.uk

Nature, 2011, vol. 470, issue 7332, 42-43

Abstract: Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.

Date: 2011
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DOI: 10.1038/470042a

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