MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Huadong Pei, Lindsey Zhang, Kuntian Luo, Yuxin Qin, Marta Chesi, Frances Fei, P. Leif Bergsagel, Liewei Wang, Zhongsheng You and Zhenkun Lou ()
Additional contact information
Huadong Pei: Mayo Clinic
Lindsey Zhang: Washington University
Kuntian Luo: Mayo Clinic
Yuxin Qin: Mayo Clinic
Marta Chesi: Comprehensive Cancer Center, Mayo Clinic Arizona
Frances Fei: Washington University
P. Leif Bergsagel: Comprehensive Cancer Center, Mayo Clinic Arizona
Liewei Wang: Mayo Clinic
Zhongsheng You: Washington University
Zhenkun Lou: Mayo Clinic

Nature, 2011, vol. 470, issue 7332, 124-128

Abstract: DNA-repair pathways defined Recruitment of p53 binding protein 1 (53BP1) to double-strand DNA breaks is an important step in the cellular response to DNA damage. Here, the histone methyltransferase MMSET is shown to be responsible for localized increases in a histone modification that is involved in recruiting 53BP1. The mechanism of MMSET recruitment to DNA damage sites is also investigated.

Date: 2011
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DOI: 10.1038/nature09658

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