Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

Cuong Q. Diep, Dongdong Ma, Rahul C. Deo, Teresa M. Holm, Richard W. Naylor, Natasha Arora, Rebecca A. Wingert, Frank Bollig, Gordana Djordjevic, Benjamin Lichman, Hao Zhu, Takanori Ikenaga, Fumihito Ono, Christoph Englert, Chad A. Cowan, Neil A. Hukriede, Robert I. Handin and Alan J. Davidson ()
Additional contact information
Cuong Q. Diep: Center for Regenerative Medicine, Massachusetts General Hospital
Dongdong Ma: Harvard Medical School
Rahul C. Deo: Center for Regenerative Medicine, Massachusetts General Hospital
Teresa M. Holm: Center for Regenerative Medicine, Massachusetts General Hospital
Richard W. Naylor: Center for Regenerative Medicine, Massachusetts General Hospital
Natasha Arora: Center for Regenerative Medicine, Massachusetts General Hospital
Rebecca A. Wingert: Center for Regenerative Medicine, Massachusetts General Hospital
Frank Bollig: Leibniz Institute for Age Research, Fritz Lipmann Institute
Gordana Djordjevic: Center for Regenerative Medicine, Massachusetts General Hospital
Benjamin Lichman: Center for Regenerative Medicine, Massachusetts General Hospital
Hao Zhu: Dana-Farber Cancer Institute
Takanori Ikenaga: Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism
Fumihito Ono: Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism
Christoph Englert: Leibniz Institute for Age Research, Fritz Lipmann Institute
Chad A. Cowan: Center for Regenerative Medicine, Massachusetts General Hospital
Neil A. Hukriede: University of Pittsburgh, School of Medicine
Robert I. Handin: Harvard Medical School
Alan J. Davidson: Center for Regenerative Medicine, Massachusetts General Hospital

Nature, 2011, vol. 470, issue 7332, 95-100

Abstract: Adult kidney regeneration Fish can regenerate nephrons — the functional units of the kidney — following kidney injury, whereas adult mammals lack this ability. A previously unknown type of kidney cell responsible for this regeneration has now been discovered in adult zebrafish, where they are found in small aggregations throughout the kidney. When as few as 10–20 of these progenitor cells are transplanted into injured adult kidneys, they engraft and form new, functional nephrons. This suggests that it might be possible to identify an equivalent regenerative cell in humans for therapeutic purposes.

Date: 2011
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DOI: 10.1038/nature09669

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