Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Jason R. Spence, Christopher N. Mayhew, Scott A. Rankin, Matthew F. Kuhar, Jefferson E. Vallance, Kathryn Tolle, Elizabeth E. Hoskins, Vladimir V. Kalinichenko, Susanne I. Wells, Aaron M. Zorn, Noah F. Shroyer and James M. Wells ()
Additional contact information
Jason R. Spence: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Christopher N. Mayhew: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Scott A. Rankin: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Matthew F. Kuhar: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Jefferson E. Vallance: Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Kathryn Tolle: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Elizabeth E. Hoskins: 3333 Burnet Avenue
Vladimir V. Kalinichenko: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Susanne I. Wells: 3333 Burnet Avenue
Aaron M. Zorn: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Noah F. Shroyer: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
James M. Wells: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA

Nature, 2011, vol. 470, issue 7332, 105-109

Abstract: Intestinal tissue made in vitro Using a sequence of growth-factor manipulations to mimic embryonic intestinal development in culture, a new study has successfully generated human intestinal tissue in vitro from embryonic and induced pluripotent stem cells. The resulting epithelium was uniformly intestinal, with villus-like structures and progenitor domains, and contained all of the functional cell types of the gut, including brush borders that were indistinguishable from adult intestine. This approach may provide therapeutic benefit for disease studies.

Date: 2011
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DOI: 10.1038/nature09691

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