Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina

Ryota L. Matsuoka, Kim T. Nguyen-Ba-Charvet, Aijaz Parray, Tudor C. Badea, Alain Chédotal and Alex L. Kolodkin ()
Additional contact information
Ryota L. Matsuoka: The Johns Hopkins University School of Medicine
Kim T. Nguyen-Ba-Charvet: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
Aijaz Parray: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
Tudor C. Badea: The Johns Hopkins University School of Medicine
Alain Chédotal: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
Alex L. Kolodkin: The Johns Hopkins University School of Medicine

Nature, 2011, vol. 470, issue 7333, 259-263

Abstract: Molecular cue in the developing retina The retina is a laminated structure made up of several different cellular subtypes, interconnected according to a precise architecture that is vital for proper visual perception. Matsuoka et al. shed new light on the molecular mechanisms governing the development of these circuits. Transmembrane molecules — typically most active as repulsive signals during axonal guidance — exhibit specific expression patterns within the retina that promote appropriate connectivity between cell types. Mutant mice lacking specific isoforms of these semaphorin or plexin molecular families display significant defects in retinal circuitry. Thus, repulsive cues present on the neuronal processes themselves drive proper wiring between lamina within the retina.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature09675 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:470:y:2011:i:7333:d:10.1038_nature09675

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09675

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().