SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Zhihu Ding, Chang-Jiun Wu, Gerald C. Chu, Yonghong Xiao, Dennis Ho, Jingfang Zhang, Samuel R. Perry, Emma S. Labrot, Xiaoqiu Wu, Rosina Lis, Yujin Hoshida, David Hiller, Baoli Hu, Shan Jiang, Hongwu Zheng, Alexander H. Stegh, Kenneth L. Scott, Sabina Signoretti, Nabeel Bardeesy, Y. Alan Wang, David E. Hill, Todd R. Golub, Meir J. Stampfer, Wing H. Wong, Massimo Loda, Lorelei Mucci, Lynda Chin () and Ronald A. DePinho ()
Additional contact information
Zhihu Ding: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Chang-Jiun Wu: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Gerald C. Chu: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Yonghong Xiao: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Dennis Ho: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Jingfang Zhang: McArdle Lab for Cancer Research, University of Wisconsin
Samuel R. Perry: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Emma S. Labrot: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Xiaoqiu Wu: Dana-Farber Cancer Institute
Rosina Lis: Dana-Farber Cancer Institute
Yujin Hoshida: Pediatric Oncology, Dana-Farber Cancer Institute
David Hiller: Stanford University
Baoli Hu: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Shan Jiang: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Hongwu Zheng: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Alexander H. Stegh: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Kenneth L. Scott: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Sabina Signoretti: Renal Cancer Program, Dana-Farber/Harvard Cancer Center
Nabeel Bardeesy: Massachusetts General Hospital Cancer Center
Y. Alan Wang: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
David E. Hill: Harvard Medical School
Todd R. Golub: Pediatric Oncology, Dana-Farber Cancer Institute
Meir J. Stampfer: Harvard School of Public Health
Wing H. Wong: Stanford University
Massimo Loda: Dana-Farber Cancer Institute
Lorelei Mucci: Harvard School of Public Health
Lynda Chin: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Ronald A. DePinho: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute

Nature, 2011, vol. 470, issue 7333, 269-273

Abstract: Four-gene marker in prostate cancer Using a Smad4/Pten null transgenic mouse model of prostate cancer, Ding et al. show that the transforming growth factor-β (TGFβ) signalling pathway limits tumour progression and metastasis. By utilizing markers of this pathway and other biologically relevant factors, they develop a four-gene signature that is associated with poorer clinical outcome and metastatic progression in several prostate cancer cohorts, especially in combination with other clinical parameters. This signature may prove useful as a basis for an improved prognostic test for those cases of prostate cancer in which deciding on the right treatment regime while avoiding over-treatment is an important clinical challenge.

Date: 2011
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DOI: 10.1038/nature09677

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