A unique chromatin signature uncovers early developmental enhancers in humans

Alvaro Rada-Iglesias, Ruchi Bajpai, Tomek Swigut, Samantha A. Brugmann, Ryan A. Flynn and Joanna Wysocka ()
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Alvaro Rada-Iglesias: Stanford University School of Medicine
Ruchi Bajpai: Stanford University School of Medicine
Tomek Swigut: Stanford University School of Medicine
Samantha A. Brugmann: Stanford University School of Medicine
Ryan A. Flynn: Stanford University School of Medicine
Joanna Wysocka: Stanford University School of Medicine

Nature, 2011, vol. 470, issue 7333, 279-283

Abstract: Early enhancers revealed Identifying the genomic regulatory sequences, such as enhancers, that control early embryonic development remains a difficult challenge. Profiling of histone modifications and chromatin regulators in human embryonic stem cells now reveals unique signatures that are used to identify more than 2,000 putative enhancers. These enhancers are either active in the embryonic stem cells or are associated with early developmental genes.

Date: 2011
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DOI: 10.1038/nature09692

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