lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

Chenguang Gong and Lynne E. Maquat ()
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Chenguang Gong: School of Medicine and Dentistry, University of Rochester
Lynne E. Maquat: School of Medicine and Dentistry, University of Rochester

Nature, 2011, vol. 470, issue 7333, 284-288

Abstract: Role for long non-coding RNAs The RNA-binding protein Staufen1 (STAU1) promotes the degradation of double-stranded messenger RNA in the process known as Staufen-mediated decay (SMD). STAU1 binds to transcripts in the 3′ untranslated region (UTR), and although a specific stem-loop binding site had been defined for one SMD target, it was unclear how STAU1 was directed to other SMD targets that lack this structure. Chenguang Gong and Lynne Maquat report that pairing of Alu element sequences in long non-coding RNAs (lncRNAs) and in the 3′ UTR of the SMD target generates a double-stranded RNA structure that STAU1 recognizes. This result highlights a new function for lncRNAs.

Date: 2011
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DOI: 10.1038/nature09701

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