Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

Daniel Cortázar, Christophe Kunz, Jim Selfridge, Teresa Lettieri, Yusuke Saito, Eilidh MacDougall, Annika Wirz, David Schuermann, Angelika L. Jacobs, Fredy Siegrist, Roland Steinacher, Josef Jiricny, Adrian Bird and Primo Schär ()
Additional contact information
Daniel Cortázar: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Christophe Kunz: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Jim Selfridge: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Teresa Lettieri: Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, Switzerland
Yusuke Saito: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Eilidh MacDougall: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Annika Wirz: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
David Schuermann: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Angelika L. Jacobs: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Fredy Siegrist: Pharmaceutical Research, Global Preclinical Safety, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland
Roland Steinacher: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
Josef Jiricny: Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, Switzerland
Adrian Bird: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Primo Schär: Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland

Nature, 2011, vol. 470, issue 7334, 419-423

Abstract: DNA repair role in cell differentiation The DNA repair enzyme thymine DNA glycolase (TDG) has been implicated in gene regulation, but its biological functions are unclear. Tdg gene knockouts in mice now reveal that the enzyme is essential for embryonic development, acting to maintain active and bivalent chromatin states during cell differentiation. TDG-dependent DNA repair may therefore have evolved to maintain epigenetic stability in lineage-committed cells.

Date: 2011
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DOI: 10.1038/nature09672

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