CKIα ablation highlights a critical role for p53 in invasiveness control

Ela Elyada, Ariel Pribluda, Robert E. Goldstein, Yael Morgenstern, Guy Brachya, Gady Cojocaru, Irit Snir-Alkalay, Ido Burstain, Rebecca Haffner-Krausz, Steffen Jung, Zoltan Wiener, Kari Alitalo, Moshe Oren, Eli Pikarsky () and Yinon Ben-Neriah ()
Additional contact information
Ela Elyada: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Ariel Pribluda: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Robert E. Goldstein: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Yael Morgenstern: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Guy Brachya: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Gady Cojocaru: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Irit Snir-Alkalay: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Ido Burstain: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Rebecca Haffner-Krausz: The Weizmann Institute of Science, Rehovot 76100, Israel
Steffen Jung: The Weizmann Institute of Science, Rehovot 76100, Israel
Zoltan Wiener: Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland
Kari Alitalo: Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland
Moshe Oren: The Weizmann Institute of Science, Rehovot 76100, Israel
Eli Pikarsky: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
Yinon Ben-Neriah: The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel

Nature, 2011, vol. 470, issue 7334, 409-413

Abstract: The role of p53 in metastasis In a mouse model of intestinal cancer, Yinon Ben-Neriah and colleagues show that in the absence of CK1-α, the loss of p53 dramatically enhances tumour progression and metastasis. The tumour repressor p53 normally limits cancer cell invasion through the regulation of p21 and a set of invasion genes that include Prox1. This study adds more detail to the emerging picture that during tumour development, the p53 gene not only controls cell death and proliferation but also metastasis.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09673 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09673

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09673

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().