The novel gene twenty-four defines a critical translational step in the Drosophila clock

Chunghun Lim, Jongbin Lee, Changtaek Choi, Valerie L. Kilman, Juwon Kim, Sung Mi Park, Sung Key Jang, Ravi Allada () and Joonho Choe ()
Additional contact information
Chunghun Lim: Northwestern University
Jongbin Lee: Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Changtaek Choi: Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Valerie L. Kilman: Northwestern University
Juwon Kim: Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Sung Mi Park: Pohang University of Science and Technology, Pohang 790-784, Korea
Sung Key Jang: Pohang University of Science and Technology, Pohang 790-784, Korea
Ravi Allada: Northwestern University
Joonho Choe: Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

Nature, 2011, vol. 470, issue 7334, 399-403

Abstract: Fly by night — and day Gene expression in multicellular organisms fluctuates in line with the day/night cycle, resulting in differential behaviours throughout the day. These changes in expression have been widely studied at the transcriptional and post-translational levels. A further type of circadian-influenced regulation has now been identified in the fruitfly Drosophila. A gene termed twenty-four (twf) is shown to have a role in an under-appreciated aspect of the clock pathway, the translation of a clock component from RNA to protein. The twenty-four protein associates with the mRNA of the clock protein PER, enhancing its translation.

Date: 2011
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DOI: 10.1038/nature09728

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