Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

Wei Tan, Weizhou Zhang, Amy Strasner, Sergei Grivennikov, Jin Q. Cheng, Robert M. Hoffman and Michael Karin ()
Additional contact information
Wei Tan: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA
Weizhou Zhang: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA
Amy Strasner: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA
Sergei Grivennikov: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA
Jin Q. Cheng: H. Lee Moffitt Cancer Center
Robert M. Hoffman: University of California San Diego
Michael Karin: Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0723, La Jolla, California 92093, USA

Nature, 2011, vol. 470, issue 7335, 548-553

Abstract: Metastasis in breast cancer In a mouse model of ErbB-driven mammary tumours, Tan et al. find a role for RANKL (receptor activator of nuclear factor-κB ligand) in the formation of lung metastases. RANKL is produced by regulatory T cells infiltrating the primary tumours, and acts through its receptor RANK, which is expressed on the cancer cells. Targeting RANKL may therefore prove useful in reducing breast cancer metastases.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09707 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09707

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09707

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().