Programming the magnitude and persistence of antibody responses with innate immunity

Sudhir Pai Kasturi, Ioanna Skountzou, Randy A. Albrecht, Dimitrios Koutsonanos, Tang Hua, Helder I. Nakaya, Rajesh Ravindran, Shelley Stewart, Munir Alam, Marcin Kwissa, Francois Villinger, Niren Murthy, John Steel, Joshy Jacob, Robert J. Hogan, Adolfo García-Sastre, Richard Compans and Bali Pulendran ()
Additional contact information
Sudhir Pai Kasturi: Emory Vaccine Center, Emory University
Ioanna Skountzou: Emory Vaccine Center, Emory University
Randy A. Albrecht: Mount Sinai School of Medicine
Dimitrios Koutsonanos: Emory University
Tang Hua: Emory Vaccine Center, Emory University
Helder I. Nakaya: Emory Vaccine Center, Emory University
Rajesh Ravindran: Emory Vaccine Center, Emory University
Shelley Stewart: Duke Human Vaccine Institute, Duke University Medical Center
Munir Alam: Duke Human Vaccine Institute, Duke University Medical Center
Marcin Kwissa: Emory Vaccine Center, Emory University
Francois Villinger: Emory Vaccine Center, Emory University
Niren Murthy: Georgia Institute of Technology
John Steel: Mount Sinai School of Medicine
Joshy Jacob: Emory Vaccine Center, Emory University
Robert J. Hogan: College of Veterinary Medicine, University of Georgia
Adolfo García-Sastre: Mount Sinai School of Medicine
Richard Compans: Emory Vaccine Center, Emory University
Bali Pulendran: Emory Vaccine Center, Emory University

Nature, 2011, vol. 470, issue 7335, 543-547

Abstract: Vaccines given a boost A feature of many successful vaccines is the induction of memory B cells and long-lived plasma cells that can secrete neutralizing antibodies for a lifetime. The mechanisms that stimulate such persistent responses remain poorly understood. Bali Pulendran and colleagues show that nanoparticles containing two Toll-like receptor ligands, proteins with important roles in innate immunity, can boost the magnitude and persistence of vaccine-elicited antibody responses in primates, improving vaccine-mediated protection against influenza virus.

Date: 2011
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DOI: 10.1038/nature09737

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