Co-directional replication–transcription conflicts lead to replication restart

Houra Merrikh, Cristina Machón, William H. Grainger, Alan D. Grossman () and Panos Soultanas ()
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Houra Merrikh: Building 68-530, M.I.T.
Cristina Machón: Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park
William H. Grainger: Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park
Alan D. Grossman: Building 68-530, M.I.T.
Panos Soultanas: Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park

Nature, 2011, vol. 470, issue 7335, 554-557

Abstract: Transcription and replication in conflict As the rates of DNA replication and transcription are different, the machineries that carry out these processes are bound to clash sometimes on the DNA helix. In contrast to results from head-on collisions, co-directional encounters have been shown to have mild effects in vitro, requiring no additional replication restart factors. Alan Grossman, Panos Soultanas and colleagues now show that in bacterial cells, highly transcribed genes are 'hotspots' for conflicts between transcription and replication. Such conflicts cause replication to pause or stall, and both types of events require the activities of restart proteins to resume replication.

Date: 2011
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DOI: 10.1038/nature09758

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