Tumour evolution inferred by single-cell sequencing

Nicholas Navin, Jude Kendall, Jennifer Troge, Peter Andrews, Linda Rodgers, Jeanne McIndoo, Kerry Cook, Asya Stepansky, Dan Levy, Diane Esposito, Lakshmi Muthuswamy, Alex Krasnitz, W. Richard McCombie, James Hicks and Michael Wigler ()
Additional contact information
Nicholas Navin: Cold Spring Harbor Laboratory, Cold Spring Harbor
Jude Kendall: Cold Spring Harbor Laboratory, Cold Spring Harbor
Jennifer Troge: Cold Spring Harbor Laboratory, Cold Spring Harbor
Peter Andrews: Cold Spring Harbor Laboratory, Cold Spring Harbor
Linda Rodgers: Cold Spring Harbor Laboratory, Cold Spring Harbor
Jeanne McIndoo: Cold Spring Harbor Laboratory, Cold Spring Harbor
Kerry Cook: Cold Spring Harbor Laboratory, Cold Spring Harbor
Asya Stepansky: Cold Spring Harbor Laboratory, Cold Spring Harbor
Dan Levy: Cold Spring Harbor Laboratory, Cold Spring Harbor
Diane Esposito: Cold Spring Harbor Laboratory, Cold Spring Harbor
Lakshmi Muthuswamy: Ontario Institute for Cancer Research
Alex Krasnitz: Cold Spring Harbor Laboratory, Cold Spring Harbor
W. Richard McCombie: Cold Spring Harbor Laboratory, Cold Spring Harbor
James Hicks: Cold Spring Harbor Laboratory, Cold Spring Harbor
Michael Wigler: Cold Spring Harbor Laboratory, Cold Spring Harbor

Nature, 2011, vol. 472, issue 7341, 90-94

Abstract: Single tumour cells observed Tumours are known to be genetically heterogeneous, but it is proving difficult to dissect this heterogeneity at the single-cell level. A combination of whole-genome amplification and sequencing of single nuclei separated by fluorescence activated cell sorting now reveals the population structure of breast tumours from two patients. In both, tumour growth is by punctuated clonal expansions with few persistent intermediates, in contrast to the many gradual models of tumour progression. Single-cell sequencing of this type — once it becomes cheaper — is likely to have clinical implications for cancer prognosis and staging.

Date: 2011
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DOI: 10.1038/nature09807

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