A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Kevin C. Wang, Yul W. Yang, Bo Liu, Amartya Sanyal, Ryan Corces-Zimmerman, Yong Chen, Bryan R. Lajoie, Angeline Protacio, Ryan A. Flynn, Rajnish A. Gupta, Joanna Wysocka, Ming Lei, Job Dekker, Jill A. Helms and Howard Y. Chang ()
Additional contact information
Kevin C. Wang: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Yul W. Yang: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Bo Liu: Stanford University School of Medicine
Amartya Sanyal: Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Ryan Corces-Zimmerman: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Yong Chen: Howard Hughes Medical Institute, University of Michigan Medical School
Bryan R. Lajoie: Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Angeline Protacio: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Ryan A. Flynn: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Rajnish A. Gupta: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Joanna Wysocka: Stanford University School of Medicine
Ming Lei: Howard Hughes Medical Institute, University of Michigan Medical School
Job Dekker: Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Jill A. Helms: Stanford University School of Medicine
Howard Y. Chang: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine

Nature, 2011, vol. 472, issue 7341, 120-124

Abstract: Long-range genetic regulation A major question in developmental biology is how functionally related groups of genes are switched on at the right time and in the right place. Long intergenic non-coding RNAs (lincRNAs) have been implicated in both gene silencing and activation, and could be a means of long-range control of gene expression. A lincRNA termed HOTTIP that coordinates the activation of multiple 5' HOXA regulatory genes has now been identified at the 5' tip of the HOXA locus. Chromosomal looping brings HOTTIP close its target genes, where it facilitates histone H3 lysine 4 trimethylation and gene transcription.

Date: 2011
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DOI: 10.1038/nature09819

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