Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice

Yan Liu, Yun’ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen and Yi Rao ()
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Yan Liu: National Institute of Biological Sciences
Yun’ai Jiang: National Institute of Biological Sciences
Yunxia Si: National Institute of Biological Sciences
Ji-Young Kim: Psychiatry and Developmental Biology, and the Pain Center, Washington University, School of Medicine
Zhou-Feng Chen: Psychiatry and Developmental Biology, and the Pain Center, Washington University, School of Medicine
Yi Rao: National Institute of Biological Sciences

Nature, 2011, vol. 472, issue 7341, 95-99

Abstract: A neural link to the sex drive To whom should a male direct his efforts to find a mate? Little is known about the mechanisms controlling this fundamental social interaction in mammals. Now it is reported that serotonergic neuron signalling stabilizes sexual preference in mice. Loss of the neurotransmitter serotonin (5-hydroxytryptamine) through knockout of tryptophan hydroxylase 2 causes indiscriminate mating behaviour in male mice. This suggests a role for serotonergic signalling in sexual interactions, and more generally for neurotransmitters in social relationships.

Date: 2011
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DOI: 10.1038/nature09822

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