Dampening of death pathways by schnurri-2 is essential for T-cell development

Tracy L. Staton, Vanja Lazarevic, Dallas C. Jones, Amanda J. Lanser, Tsuyoshi Takagi, Shunsuke Ishii and Laurie H. Glimcher ()
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Tracy L. Staton: Harvard School of Public Health
Vanja Lazarevic: Harvard School of Public Health
Dallas C. Jones: Harvard School of Public Health
Amanda J. Lanser: Harvard School of Public Health
Tsuyoshi Takagi: Laboratory of Molecular Genetics, RIKEN Tsukuba Institute
Shunsuke Ishii: Laboratory of Molecular Genetics, RIKEN Tsukuba Institute
Laurie H. Glimcher: Harvard School of Public Health

Nature, 2011, vol. 472, issue 7341, 105-109

Abstract: The path to T cells not dead cells Considerable study has focused on how thymocytes — progenitors in the thymus that produce T lymphocytes — distinguish between signal intensities leading to the opposing fates of differentiation and death. However, the mechanisms that maintain these boundaries remain unknown. The zinc-finger-containing protein schnurri-2 is now shown to regulate positive selection in T-cell development by dampening the mitochondrial death pathway.

Date: 2011
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DOI: 10.1038/nature09848

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