Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

Kunyoo Shin (), John Lee, Nini Guo, James Kim, Agnes Lim, Lishu Qu, Indira U. Mysorekar and Philip A. Beachy ()
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Kunyoo Shin: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine
John Lee: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine
Nini Guo: Johns Hopkins University School of Medicine
James Kim: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine
Agnes Lim: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine
Lishu Qu: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine
Indira U. Mysorekar: Washington University School of Medicine
Philip A. Beachy: Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 2011, vol. 472, issue 7341, 110-114

Abstract: Signalling epidermal growth The maintenance and regeneration of the adult bladder epithelium is poorly understood, yet it is clinically relevant to the development of urinary-tract infections and bladder cancer. A new study provides insight into the cellular and molecular mechanisms underlying the regenerative response to injury within the mammalian urinary bladder. On injury by bacterial infection or chemical agents, a Shh and Wnt signalling feedback circuit between basal cells of the urothelium and the stromal cells that underlie them leads to regenerative proliferation of the bladder epithelia.

Date: 2011
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DOI: 10.1038/nature09851

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