Cortical representations of olfactory input by trans-synaptic tracing

Kazunari Miyamichi, Fernando Amat, Farshid Moussavi, Chen Wang, Ian Wickersham, Nicholas R. Wall, Hiroki Taniguchi, Bosiljka Tasic, Z. Josh Huang, Zhigang He, Edward M. Callaway, Mark A. Horowitz and Liqun Luo ()
Additional contact information
Kazunari Miyamichi: Stanford University
Fernando Amat: Stanford University
Farshid Moussavi: Stanford University
Chen Wang: Children’s Hospital
Ian Wickersham: Systems Neurobiology Laboratory, The Salk Institute for Biological Studies and Neurosciences Graduate Program, University of California
Nicholas R. Wall: Systems Neurobiology Laboratory, The Salk Institute for Biological Studies and Neurosciences Graduate Program, University of California
Hiroki Taniguchi: Cold Spring Harbor Laboratory
Bosiljka Tasic: Stanford University
Z. Josh Huang: Cold Spring Harbor Laboratory
Zhigang He: Children’s Hospital
Edward M. Callaway: Systems Neurobiology Laboratory, The Salk Institute for Biological Studies and Neurosciences Graduate Program, University of California
Mark A. Horowitz: Stanford University
Liqun Luo: Stanford University

Nature, 2011, vol. 472, issue 7342, 191-196

Abstract: Abstract In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map. However, it is unclear how this map is represented in the olfactory cortex. Here we combine rabies-virus-dependent retrograde mono-trans-synaptic labelling with genetics to control the location, number and type of ‘starter’ cortical neurons, from which we trace their presynaptic neurons. We find that individual cortical neurons receive input from multiple mitral cells representing broadly distributed glomeruli. Different cortical areas represent the olfactory bulb input differently. For example, the cortical amygdala preferentially receives dorsal olfactory bulb input, whereas the piriform cortex samples the whole olfactory bulb without obvious bias. These differences probably reflect different functions of these cortical areas in mediating innate odour preference or associative memory. The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system.

Date: 2011
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DOI: 10.1038/nature09714

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