Structure and mechanism of the uracil transporter UraA

Feiran Lu, Shuo Li, Yang Jiang, Jing Jiang, He Fan, Guifeng Lu, Dong Deng, Shangyu Dang, Xu Zhang, Jiawei Wang and Nieng Yan ()
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Feiran Lu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Shuo Li: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Yang Jiang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Jing Jiang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
He Fan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Guifeng Lu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Dong Deng: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Shangyu Dang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Xu Zhang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Jiawei Wang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Nieng Yan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University

Nature, 2011, vol. 472, issue 7342, 243-246

Abstract: Nucleobase and vitamin C transport Nucleobase/ascorbate transporter (NAT) proteins are responsible for the uptake of nucleotide bases by many organisms and for the transport of vitamin C in mammals. Here Lu et al. present the first X-ray crystal structure of an NAT protein, the uracil:H+ symporter UraA from Escherichia coli. The protein consists of a core domain and a gate domain, and uracil is found at the interface between the two domains. Structural and biochemical analyses suggest how uracil transport occurs and how it is coupled to the transport of a proton.

Date: 2011
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DOI: 10.1038/nature09885

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