Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons

Sulagna Ghosh, Stephen D. Larson, Hooman Hefzi, Zachary Marnoy, Tyler Cutforth, Kartheek Dokka and Kristin K. Baldwin ()
Additional contact information
Sulagna Ghosh: Dorris Neuroscience Center, The Scripps Research Institute
Stephen D. Larson: Program in Neurosciences, National Center for Microscopy and Imaging Research, University of California
Hooman Hefzi: Dorris Neuroscience Center, The Scripps Research Institute
Zachary Marnoy: Dorris Neuroscience Center, The Scripps Research Institute
Tyler Cutforth: Cell and Developmental Biology, University of California
Kartheek Dokka: Dorris Neuroscience Center, The Scripps Research Institute
Kristin K. Baldwin: Dorris Neuroscience Center, The Scripps Research Institute

Nature, 2011, vol. 472, issue 7342, 217-220

Abstract: Scent tracking In the mouse, glomeruli in the olfactory bulb receive projections from single classes of olfactory neurons, thereby forming an odour map. Information from the glomeruli is then relayed to the cortex but the projection patterns from individual glomeruli are not known. Three papers now examine the details of this projection. Luo and colleagues use a combination of genetics and retrograde mono-trans-synaptic rabies virus labelling. They trace the presynaptic connections of individual cortical neurons and find no evidence of connections supporting a stereotyped odour map in the cortex, but see systematic topographical differences in amygdala connectivity. The lack of stereotypical cortical projection is corroborated, both at the level of bulk axonal patterning and in projections of individually labelled neurons, by two papers — one from the Axel laboratory, and one from the Baldwin laboratory — that examine the anterograde projections from individual glomeruli. Together, these findings provide anatomical evidence for combinatorial processing of information from diverse glomeruli by cortical neurons and may also reflect different functions of various areas in mediating innate or learned odour preferences.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09945 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:472:y:2011:i:7342:d:10.1038_nature09945

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09945

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().