A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Damian F. Brennan, Arvin C. Dar, Nicholas T. Hertz, William C. H. Chao, Alma L. Burlingame, Kevan M. Shokat () and David Barford ()
Additional contact information
Damian F. Brennan: Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Arvin C. Dar: University of California San Francisco
Nicholas T. Hertz: University of California San Francisco
William C. H. Chao: Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Alma L. Burlingame: University of California San Francisco
Kevan M. Shokat: University of California San Francisco
David Barford: Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK

Nature, 2011, vol. 472, issue 7343, 366-369

Abstract: Allostery in kinase suppressor of RAS The RAS–RAF–MEK–ERK signalling pathway is important in the regulation of cell proliferation and is often aberrantly activated in cancer. KSR (kinase suppressor of RAS) is essential for RAS signaling, but its mechanism of action has been unclear. It is a member of the protein kinase family but was thought to be a pseudokinase with only scaffold functions. Structural and biochemical studies now reveal that KSR can function as a kinase, and by forming a heterodimer with BRAF, it relays an activating signal to MEK. This work points to KSR as a potential drug target in the RAS–ERK signalling pathway.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09860 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09860

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09860

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().