Neuronal activity is required for the development of specific cortical interneuron subtypes

Natalia V. De Marco García, Theofanis Karayannis and Gord Fishell ()
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Natalia V. De Marco García: Smilow Neuroscience Program, New York University Langone Medical Center
Theofanis Karayannis: Smilow Neuroscience Program, New York University Langone Medical Center
Gord Fishell: Smilow Neuroscience Program, New York University Langone Medical Center

Nature, 2011, vol. 472, issue 7343, 351-355

Abstract: Active migrating neurons Interneurons migrate long distances before settling into a specific microcircuit. Because these cells are known to participate in correlated network activity, it is possible that electrical inputs may influence migration and integration. By manipulating neuronal activity in subsets of developing interneurons, Fishell and colleagues find that proper migration does indeed depend on this activity, involving a transcription-factor signalling pathway specific to those interneuron cell types.

Date: 2011
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DOI: 10.1038/nature09865

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