Genome-wide analysis reveals novel molecular features of mouse recombination hotspots

Fatima Smagulova, Ivan V. Gregoretti, Kevin Brick, Pavel Khil, R. Daniel Camerini-Otero () and Galina V. Petukhova ()
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Fatima Smagulova: Uniformed Services University of the Health Sciences
Ivan V. Gregoretti: National Institute of Diabetes, Digestive and Kidney Diseases, NIH
Kevin Brick: National Institute of Diabetes, Digestive and Kidney Diseases, NIH
Pavel Khil: National Institute of Diabetes, Digestive and Kidney Diseases, NIH
R. Daniel Camerini-Otero: National Institute of Diabetes, Digestive and Kidney Diseases, NIH
Galina V. Petukhova: Uniformed Services University of the Health Sciences

Nature, 2011, vol. 472, issue 7343, 375-378

Abstract: Hot spots for meiotic recombination To initiate the recombination process that guides accurate chromosome segregation during meiosis, programmed double-strand breaks are made at preferred sites known as hot spots. Petukhova and colleagues have now achieved high-resolution genome-wide mapping of meiotic double-strand breaks in mouse cells. The method employed is independent of the availability of genetic markers, a limitation of previous approaches. With these data they have uncovered several features of hot spots at both the sequence and chromatin levels.

Date: 2011
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DOI: 10.1038/nature09869

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