Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

Ikuhiro Okamoto, Catherine Patrat, Dominique Thépot, Nathalie Peynot, Patricia Fauque, Nathalie Daniel, Patricia Diabangouaya, Jean-Philippe Wolf, Jean-Paul Renard, Véronique Duranthon () and Edith Heard ()
Additional contact information
Ikuhiro Okamoto: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934
Catherine Patrat: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934
Dominique Thépot: INRA UMR 1198 Biologie du Développement et de la Reproduction
Nathalie Peynot: INRA UMR 1198 Biologie du Développement et de la Reproduction
Patricia Fauque: Laboratoire de Biologie de la reproduction CECOS, CHU de Dijon, Université de Bourgogne
Nathalie Daniel: INRA UMR 1198 Biologie du Développement et de la Reproduction
Patricia Diabangouaya: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934
Jean-Philippe Wolf: Unité Inserm 1016, Université Paris Descartes – Assistance Publique Hôpitaux de Paris – Service de Biologie de la Reproduction, Hôpital Cochin
Jean-Paul Renard: INRA UMR 1198 Biologie du Développement et de la Reproduction
Véronique Duranthon: INRA UMR 1198 Biologie du Développement et de la Reproduction
Edith Heard: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934

Nature, 2011, vol. 472, issue 7343, 370-374

Abstract: Mice out of step on X inactivation X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits and humans shows that the processes in mice, in which most of previous analyses have been done, differ significantly from those in other eutherian species. The study highlights a diversity in X-inactivation regulation that may reflect the changing nature of developmental processes during evolution.

Date: 2011
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DOI: 10.1038/nature09872

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