A transient placental source of serotonin for the fetal forebrain

Alexandre Bonnin (), Nick Goeden, Kevin Chen, Melissa L. Wilson, Jennifer King, Jean C. Shih, Randy D. Blakely, Evan S. Deneris and Pat Levitt ()
Additional contact information
Alexandre Bonnin: Zilkha Neurogenetic Institute, Keck School of Medicine of USC
Nick Goeden: Zilkha Neurogenetic Institute, Keck School of Medicine of USC
Kevin Chen: USC School of Pharmacy
Melissa L. Wilson: Keck School of Medicine of USC
Jennifer King: Keck School of Medicine of USC
Jean C. Shih: USC School of Pharmacy
Randy D. Blakely: Vanderbilt University Medical Center
Evan S. Deneris: Case Western Reserve University School of Medicine
Pat Levitt: Zilkha Neurogenetic Institute, Keck School of Medicine of USC

Nature, 2011, vol. 472, issue 7343, 347-350

Abstract: Early sources of serotonin Although it is widely assumed that a maternal contribution to fetal serotonin (5-hydroxytryptamine or 5-HT) levels during pregnancy is important in neurodevelopment, there is little direct experimental evidence to support the idea. Bonnin et al. use new techniques to determine that during early pregnancy the placenta is a significant source of 5-HT, made from maternal tryptophan precursors in both mice and humans. Later in pregnancy, an endogenous 5-HT source in the fetus takes over.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09972 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09972

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09972

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().