TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Thomas Pertel, Stéphane Hausmann, Damien Morger, Sara Züger, Jessica Guerra, Josefina Lascano, Christian Reinhard, Federico A. Santoni, Pradeep D. Uchil, Laurence Chatel, Aurélie Bisiaux, Matthew L. Albert, Caterina Strambio- De-Castillia, Walther Mothes, Massimo Pizzato, Markus G. Grütter and Jeremy Luban ()
Additional contact information
Thomas Pertel: University of Geneva
Stéphane Hausmann: University of Geneva
Damien Morger: University of Zurich
Sara Züger: University of Zurich
Jessica Guerra: University of Geneva
Josefina Lascano: University of Geneva
Christian Reinhard: University of Geneva
Federico A. Santoni: University of Geneva
Pradeep D. Uchil: Section of Microbial Pathogenesis, Yale University School of Medicine
Laurence Chatel: Novimmune SA
Aurélie Bisiaux: Institut Pasteur, Inserm U818
Matthew L. Albert: Institut Pasteur, Inserm U818
Caterina Strambio- De-Castillia: University of Geneva
Walther Mothes: Section of Microbial Pathogenesis, Yale University School of Medicine
Massimo Pizzato: University of Geneva
Markus G. Grütter: University of Zurich
Jeremy Luban: University of Geneva

Nature, 2011, vol. 472, issue 7343, 361-365

Abstract: Multi-layered antiviral activity of TRIM5 TRIM5 is an E3 ubiquitin ligase with known antiretroviral restriction factor activity, although the mechanisms involved are poorly understood. Luban and colleagues now demonstrate that TRIM5 activates innate immune signalling pathways and acts as a pattern recognition receptor specific for the retrovirus capsid lattice.

Date: 2011
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DOI: 10.1038/nature09976

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