Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Amar Sahay (), Kimberly N. Scobie, Alexis S. Hill, Colin M. O'Carroll, Mazen A. Kheirbek, Nesha S. Burghardt, André A. Fenton, Alex Dranovsky and René Hen ()
Additional contact information
Amar Sahay: Columbia University
Kimberly N. Scobie: Columbia University
Alexis S. Hill: Columbia University
Colin M. O'Carroll: Columbia University
Mazen A. Kheirbek: Columbia University
Nesha S. Burghardt: Columbia University
André A. Fenton: The Robert F. Furchgott Center for Neural and Behavioural Science, State University of New York, Downstate Medical Center
Alex Dranovsky: Columbia University
René Hen: Columbia University

Nature, 2011, vol. 472, issue 7344, 466-470

Abstract: Neurogenesis and antidepressants Loss-of-function studies have implicated adult-born hippocampal neurons — as opposed to those present at birth — in learning and memory and in mediating some effects of antidepressants. Experiments using an inducible genetic gain-of-function strategy to augment the survival of adult-born neurons in mice demonstrate a causal link between increased adult hippocampal neurogenesis and enhancement of specific cognitive functions. This raises the possibility that anxiety disorders and memory impairment might be treated by stimulating adult hippocampal neurogenesis.

Date: 2011
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DOI: 10.1038/nature09817

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