A system for the continuous directed evolution of biomolecules

Kevin M. Esvelt, Jacob C. Carlson and David R. Liu ()
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Kevin M. Esvelt: Harvard University
Jacob C. Carlson: Harvard University
David R. Liu: Harvard University

Nature, 2011, vol. 472, issue 7344, 499-503

Abstract: Speedy route to new biomolecules Many biomolecules with useful properties have been generated by laboratory molecular evolution experiments, but the processes typically take days and require frequent human intervention. Esvelt et al. now describe a phage-assisted continuous evolution system that enables the continuous, directed evolution of gene-encoded molecules that can be linked to protein production in Escherichia coli. Dozens of rounds of evolution can occur in a single day using this method, as demonstrated by the evolution of novel types of T7 RNA polymerase.

Date: 2011
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DOI: 10.1038/nature09929

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