Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

Helen S. Goodridge, Christopher N. Reyes, Courtney A. Becker, Tamiko R. Katsumoto, Jun Ma, Andrea J. Wolf, Nandita Bose, Anissa S. H. Chan, Andrew S. Magee, Michael E. Danielson, Arthur Weiss, John P. Vasilakos and David M. Underhill ()
Additional contact information
Helen S. Goodridge: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Christopher N. Reyes: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Courtney A. Becker: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Tamiko R. Katsumoto: Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California
Jun Ma: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Andrea J. Wolf: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Nandita Bose: Biothera, 3388 Mike Collins Drive
Anissa S. H. Chan: Biothera, 3388 Mike Collins Drive
Andrew S. Magee: Biothera, 3388 Mike Collins Drive
Michael E. Danielson: Biothera, 3388 Mike Collins Drive
Arthur Weiss: Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California
John P. Vasilakos: Biothera, 3388 Mike Collins Drive
David M. Underhill: IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center

Nature, 2011, vol. 472, issue 7344, 471-475

Abstract: How the innate immune system spots fungal pathogens Invading microbes are detected and ingested by white blood cells known as phagocytes. To do this they must distinguish between soluble microbe-derived components, such as pieces of cell wall, and the particulate microbes themselves. A study of the action of Dectin-1, an innate immune receptor that detects invading fungal pathogens, shows that although the receptor binds to both soluble and particulate cell-wall β-glucans, its activation is restricted to sites of contact with fungal cell walls by the formation of 'phagocytic synapses'. The phagocytic synapse provides a mechanistic model for the specific detection of ligands associated with a microbial surface, as opposed to those released from microbes at a distance.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature10071 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature10071

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10071

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().