DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

Koko Ishizuka, Atsushi Kamiya, Edwin C. Oh, Hiroaki Kanki, Saurav Seshadri, Jon F. Robinson, Hannah Murdoch, Allan J. Dunlop, Ken-ichiro Kubo, Keiko Furukori, Beverly Huang, Mariela Zeledon, Akiko Hayashi-Takagi, Hideyuki Okano, Kazunori Nakajima, Miles D. Houslay, Nicholas Katsanis () and Akira Sawa ()
Additional contact information
Koko Ishizuka: Johns Hopkins University School of Medicine
Atsushi Kamiya: Johns Hopkins University School of Medicine
Edwin C. Oh: Duke University
Hiroaki Kanki: Keio University School of Medicine
Saurav Seshadri: Johns Hopkins University School of Medicine
Jon F. Robinson: Duke University
Hannah Murdoch: Molecular Pharmacology Group, Institute of Neuroscience and Psychology, CMVLS, University of Glasgow
Allan J. Dunlop: Molecular Pharmacology Group, Institute of Neuroscience and Psychology, CMVLS, University of Glasgow
Ken-ichiro Kubo: Keio University School of Medicine
Keiko Furukori: Johns Hopkins University School of Medicine
Beverly Huang: Johns Hopkins University School of Medicine
Mariela Zeledon: Johns Hopkins University School of Medicine
Akiko Hayashi-Takagi: Johns Hopkins University School of Medicine
Hideyuki Okano: Keio University School of Medicine
Kazunori Nakajima: Keio University School of Medicine
Miles D. Houslay: Molecular Pharmacology Group, Institute of Neuroscience and Psychology, CMVLS, University of Glasgow
Nicholas Katsanis: Duke University
Akira Sawa: Johns Hopkins University School of Medicine

Nature, 2011, vol. 473, issue 7345, 92-96

Abstract: DISC1 protein as a developmental switch The schizophrenia susceptibility factor DISC1 is highly enriched in the developing cerebral cortex, suggesting that it may have an important role during this time period. Sawa and colleagues find a specific phosphorylation site that acts as a molecular switch to transform a dividing progenitor into a postmitotic, migrating neuron. In each phosphorylation state, DISC1 interacts primarily with a distinct signalling pathway. It may therefore perform a dual role in corticogenesis, dependent on its phosphorylation status.

Date: 2011
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DOI: 10.1038/nature09859

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