Functional specificity of local synaptic connections in neocortical networks

Ho Ko, Sonja B. Hofer, Bruno Pichler, Katherine A. Buchanan, P. Jesper Sjöström and Thomas D. Mrsic-Flogel ()
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Ho Ko: Physiology and Pharmacology, University College London, 21 University Street
Sonja B. Hofer: Physiology and Pharmacology, University College London, 21 University Street
Bruno Pichler: Physiology and Pharmacology, University College London, 21 University Street
Katherine A. Buchanan: Physiology and Pharmacology, University College London, 21 University Street
P. Jesper Sjöström: Physiology and Pharmacology, University College London, 21 University Street
Thomas D. Mrsic-Flogel: Physiology and Pharmacology, University College London, 21 University Street

Nature, 2011, vol. 473, issue 7345, 87-91

Abstract: Making sense of connectivity In the sensory cortex, neurons are densely interconnected, but the logic by which functionally similar and dissimilar neurons are wired together is an open question. This technical tour de force combines in vivo two-photon calcium imaging and simultaneous whole-cell recording of multiple cells to show that neurons with similar stimulus preferences connect at higher rates than those with dissimilar preferences. This points to the existence of fine-scale sub-networks dedicated to processing related sensory information. Application of this new technique more widely should reveal more about how circuits supporting different sensory or motor functions are constructed in the brain.

Date: 2011
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DOI: 10.1038/nature09880

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