Modelling schizophrenia using human induced pluripotent stem cells

Kristen J. Brennand, Anthony Simone, Jessica Jou, Chelsea Gelboin-Burkhart, Ngoc Tran, Sarah Sangar, Yan Li, Yangling Mu, Gong Chen, Diana Yu, Shane McCarthy, Jonathan Sebat and Fred H. Gage ()
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Kristen J. Brennand: Salk Institute for Biological Studies, Laboratory of Genetics
Anthony Simone: Salk Institute for Biological Studies, Laboratory of Genetics
Jessica Jou: Salk Institute for Biological Studies, Laboratory of Genetics
Chelsea Gelboin-Burkhart: Salk Institute for Biological Studies, Laboratory of Genetics
Ngoc Tran: Salk Institute for Biological Studies, Laboratory of Genetics
Sarah Sangar: Salk Institute for Biological Studies, Laboratory of Genetics
Yan Li: Salk Institute for Biological Studies, Laboratory of Genetics
Yangling Mu: Salk Institute for Biological Studies, Laboratory of Genetics
Gong Chen: Pennsylvania State University, 201 Life Science Building, University Park
Diana Yu: Salk Institute for Biological Studies, Laboratory of Genetics
Shane McCarthy: Cold Spring Harbor Laboratory, 1 Bungtown Road
Jonathan Sebat: University of California San Diego, University Of California
Fred H. Gage: Salk Institute for Biological Studies, Laboratory of Genetics

Nature, 2011, vol. 473, issue 7346, 221-225

Abstract: A model for schizophrenia Many cellular and molecular phenomena have been described in neurons of schizophrenic patients, mostly based on post-mortem data, but there is still no clear understanding of mechanisms underlying the disease. Gage and colleagues now demonstrate the feasibility of generating a human cell-based model of schizophrenia. Fibroblasts from patients with schizophrenia were reprogrammed into induced pluripotent stem cells and subsequently differentiated into neurons. These neurons displayed a number of schizophrenia-associated phenotypes, including reduced connectivity and altered gene expression, some of which could be rescued by an antipsychotic.

Date: 2011
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DOI: 10.1038/nature09915

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