A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Nikolai Windbichler, Miriam Menichelli, Philippos Aris Papathanos, Summer B. Thyme, Hui Li, Umut Y. Ulge, Blake T. Hovde, David Baker, Raymond J. Monnat, Austin Burt and Andrea Crisanti ()
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Nikolai Windbichler: Imperial College London, South Kensington Campus
Miriam Menichelli: Imperial College London, South Kensington Campus
Philippos Aris Papathanos: Imperial College London, South Kensington Campus
Summer B. Thyme: University of Washington
Hui Li: University of Washington
Umut Y. Ulge: University of Washington
Blake T. Hovde: University of Washington
David Baker: University of Washington
Raymond J. Monnat: University of Washington
Austin Burt: Imperial College London, South Kensington Campus
Andrea Crisanti: Imperial College London, South Kensington Campus

Nature, 2011, vol. 473, issue 7346, 212-215

Abstract: Manipulating an insect vector Genetic approaches to manipulating or eradicating disease vectors have been proposed as alternatives to malaria eradication. The success of this approach depends on efficient spread of a genetic modification in field populations. Windbichler et al. show that a synthetic genetic element consisting of mosquito regulatory elements and the homing endonuclease gene I-SceI can spread from a small number of individual Anopheles gambiae mosquitoes into large receptive populations in just a few generations. This is the first demonstration of a synthetic gene drive system in the main human malaria vector — and a similar approach should be applicable to many other pest species.

Date: 2011
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DOI: 10.1038/nature09937

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