Metabolite-enabled eradication of bacterial persisters by aminoglycosides

Kyle R. Allison, Mark P. Brynildsen and James J. Collins ()
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Kyle R. Allison: Howard Hughes Medical Institute, Center for Biodynamics and Center for Advanced Biotechnology, Boston University
Mark P. Brynildsen: Howard Hughes Medical Institute, Center for Biodynamics and Center for Advanced Biotechnology, Boston University
James J. Collins: Howard Hughes Medical Institute, Center for Biodynamics and Center for Advanced Biotechnology, Boston University

Nature, 2011, vol. 473, issue 7346, 216-220

Abstract: How metabolic 'helpers' kill persistent pathogens Bacterial cells can enter a dormant 'persister' state that leaves them more resistant to stress conditions, including killing by antibiotics. In a clinical setting, persister formation can lead to incomplete eradication of bacterial pathogens and treatment failure. James Collins and colleagues show that certain metabolic stimuli (including glucose and pyruvate) can increase killing of persister cells by aminoglycoside antibiotics including gentamicin. This raises the prospect that the delivery of metabolites as adjuvants to aminoglycosides could be effective in the treatment of chronic bacterial infections.

Date: 2011
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DOI: 10.1038/nature10069

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