Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

Hao Wu, Ana C. D’Alessio, Shinsuke Ito, Kai Xia, Zhibin Wang, Kairong Cui, Keji Zhao, Yi Eve Sun and Yi Zhang ()
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Hao Wu: IDDRC at Semel Institute of Neuroscience and Human Behavior, UCLA David Geffen School of Medicine
Ana C. D’Alessio: Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Shinsuke Ito: Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Kai Xia: Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Zhibin Wang: Laboratory of Human Environmental Epigenomes, Johns Hopkins Bloomberg School of Public Health
Kairong Cui: Laboratory of Molecular Immunology, The National Heart, Lung, and Blood Institute, NIH
Keji Zhao: Laboratory of Molecular Immunology, The National Heart, Lung, and Blood Institute, NIH
Yi Eve Sun: IDDRC at Semel Institute of Neuroscience and Human Behavior, UCLA David Geffen School of Medicine
Yi Zhang: Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Nature, 2011, vol. 473, issue 7347, 389-393

Abstract: Fine-tuning DNA methylation by Tet proteins The modified DNA base 5-hydroxymethylcytosine (5hmC), sometimes called the sixth base, is present in the mammalian genome where it is generated by oxidation of 5-methylcytosine (5mC; the fifth base) by enzymes of the Tet family. Four papers in this issue, from the Helin, Zhang, Rao and Reik laboratories, respectively, report on the genome-wide distribution of Tet1 and/or 5hmC in mouse embryonic stem cells using the ChIP-seq technique. Links between Tet1 and transcription regulation — both activation and repression — are revealed. Anjana Rao and colleagues also describe two alternative methods with increased sensitivity for mapping single 5hmC bases. In the associated News & Views, Nathalie Véron and Antoine H. F. M. Peters discuss what these and other recent papers reveal about the role of Tet proteins in regulating DNA methylation and gene expression.

Date: 2011
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DOI: 10.1038/nature09934

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