Neuropsin cleaves EphB2 in the amygdala to control anxiety

Benjamin K. Attwood, Julie-Myrtille Bourgognon, Satyam Patel, Mariusz Mucha, Emanuele Schiavon, Anna E. Skrzypiec, Kenneth W. Young, Sadao Shiosaka, Michal Korostynski, Marcin Piechota, Ryszard Przewlocki and Robert Pawlak ()
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Benjamin K. Attwood: University of Leicester, University Road
Julie-Myrtille Bourgognon: University of Leicester, University Road
Satyam Patel: University of Leicester, University Road
Mariusz Mucha: University of Leicester, University Road
Emanuele Schiavon: University of Leicester, University Road
Anna E. Skrzypiec: University of Leicester, University Road
Kenneth W. Young: Medical Research Council Toxicology Unit, Lancaster Road
Sadao Shiosaka: Nara Institute of Science and Technology
Michal Korostynski: Institute of Pharmacology
Marcin Piechota: Institute of Pharmacology
Ryszard Przewlocki: Institute of Pharmacology
Robert Pawlak: University of Leicester, University Road

Nature, 2011, vol. 473, issue 7347, 372-375

Abstract: Cause for anxiety Many individuals experience traumatic events, but some people seem relatively unaffected whereas others develop post-traumatic stress disorder. Now, work in mice has identified a possible cause for this variation between individuals. During stress, the serine protease neuropsin elicits plasticity in the amygdala by regulating EphB2/NMDA receptor interactions, inducing expression of the fear-related gene Fkbp5v. Mice lacking neuropsin do not exhibit the same dynamic plasticity in response to stress. These results underscore the importance of molecular pathways in the manifestation of complex behaviours such as anxiety, and point to Eph and NMDA receptors as possible therapeutic targets.

Date: 2011
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DOI: 10.1038/nature09938

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