Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Gabriella Ficz, Miguel R. Branco, Stefanie Seisenberger, Fátima Santos, Felix Krueger, Timothy A. Hore, C. Joana Marques, Simon Andrews and Wolf Reik ()
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Gabriella Ficz: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Miguel R. Branco: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Stefanie Seisenberger: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Fátima Santos: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Felix Krueger: Bioinformatics Group, The Babraham Institute
Timothy A. Hore: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
C. Joana Marques: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Simon Andrews: Bioinformatics Group, The Babraham Institute
Wolf Reik: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute

Nature, 2011, vol. 473, issue 7347, 398-402

Abstract: Fine-tuning DNA methylation by Tet proteins The modified DNA base 5-hydroxymethylcytosine (5hmC), sometimes called the sixth base, is present in the mammalian genome where it is generated by oxidation of 5-methylcytosine (5mC; the fifth base) by enzymes of the Tet family. Four papers in this issue, from the Helin, Zhang, Rao and Reik laboratories, respectively, report on the genome-wide distribution of Tet1 and/or 5hmC in mouse embryonic stem cells using the ChIP-seq technique. Links between Tet1 and transcription regulation — both activation and repression — are revealed. Anjana Rao and colleagues also describe two alternative methods with increased sensitivity for mapping single 5hmC bases. In the associated News & Views, Nathalie Véron and Antoine H. F. M. Peters discuss what these and other recent papers reveal about the role of Tet proteins in regulating DNA methylation and gene expression.

Date: 2011
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DOI: 10.1038/nature10008

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