Neural crest regulates myogenesis through the transient activation of NOTCH

Anne C. Rios, Olivier Serralbo, David Salgado and Christophe Marcelle ()
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Anne C. Rios: EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
Olivier Serralbo: EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
David Salgado: EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
Christophe Marcelle: EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia

Nature, 2011, vol. 473, issue 7348, 532-535

Abstract: A role for NOTCH in muscle development During the first days of embryonic development, somites contain stem and progenitor epithelial cells that either self-renew or undergo myogenesis. Secreted factors from surrounding tissues either activate or inhibit myogenesis in somites, but why do only a few cells at a time undergo myogenic differentiation if all cells within somites are exposed to these factors? Rios et al. show that cell fate choice in the somites is dependent on whether progenitor cells experience a transient activation of NOTCH signalling, and that this transient signal is triggered by migrating neural crest cells en route to their sites of differentiation.

Date: 2011
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DOI: 10.1038/nature09970

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