Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Scott G. Hansen, Julia C. Ford, Matthew S. Lewis, Abigail B. Ventura, Colette M. Hughes, Lia Coyne-Johnson, Nathan Whizin, Kelli Oswald, Rebecca Shoemaker, Tonya Swanson, Alfred W. Legasse, Maria J. Chiuchiolo, Christopher L. Parks, Michael K. Axthelm, Jay A. Nelson, Michael A. Jarvis, Michael Piatak, Jeffrey D. Lifson and Louis J. Picker ()
Additional contact information
Scott G. Hansen: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Julia C. Ford: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Matthew S. Lewis: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Abigail B. Ventura: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Colette M. Hughes: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Lia Coyne-Johnson: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Nathan Whizin: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Kelli Oswald: AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick
Rebecca Shoemaker: AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick
Tonya Swanson: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Alfred W. Legasse: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Maria J. Chiuchiolo: International AIDS Vaccine Initiative, Vaccine Design and Development Laboratory, 140 58th Street, Building A, Unit 8J, Brooklyn, New York 11220, USA
Christopher L. Parks: International AIDS Vaccine Initiative, Vaccine Design and Development Laboratory, 140 58th Street, Building A, Unit 8J, Brooklyn, New York 11220, USA
Michael K. Axthelm: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Jay A. Nelson: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Michael A. Jarvis: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University
Michael Piatak: AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick
Jeffrey D. Lifson: AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick
Louis J. Picker: Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University

Nature, 2011, vol. 473, issue 7348, 523-527

Abstract: Towards T-cell vaccines for HIV/AIDS Following some high-profile clinical trial failures in recent years, the emphasis in HIV/AIDS vaccine research has shifted away from T-cell-based vaccines that control viral replication towards vaccines that block acquisition of infection. Hansen et al. take a novel route to T-cell-based immunity, using cytomegalovirus (CMV) vectors. They find that vaccination with a rhesus-CMV-based vaccine against simian immunodeficiency virus (SIV) provides long-term protection from SIV challenge in rhesus macaques. Protection seems to be mediated by tissue-resident T-effector memory responses, suggesting that persistent vectors such as CMV may be effective in HIV/AIDS vaccines.

Date: 2011
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DOI: 10.1038/nature10003

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