Catalysis for fluorination and trifluoromethylation

Takeru Furuya, Adam S. Kamlet and Tobias Ritter ()
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Takeru Furuya: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Adam S. Kamlet: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Tobias Ritter: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA

Nature, 2011, vol. 473, issue 7348, 470-477

Abstract: Fluorination to the fore When incorporated into organic compounds, fluorine atoms often impart useful properties. For example, fluorination improves the thermal stability of some materials, and enhances the metabolic stability of some pharmaceuticals. Recent advances make it possible to create carbon–fluorine bonds at specific positions in complex organic molecules, paving the way for a new and potentially productive era in fluorination chemistry. In this Review, Furuya et al. describe the inherent challenges associated with carbon–fluorine bond-formation reactions, discuss the breakthroughs that have helped to overcome these problems and outline the likely direction of future research.

Date: 2011
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DOI: 10.1038/nature10108

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