Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

Yongfang Zhao, Daniel S. Terry, Lei Shi, Matthias Quick, Harel Weinstein, Scott C. Blanchard () and Jonathan A. Javitch ()
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Yongfang Zhao: Center for Molecular Recognition, Columbia University College of Physicians and Surgeons
Daniel S. Terry: Weill Medical College of Cornell University
Lei Shi: Weill Medical College of Cornell University
Matthias Quick: Center for Molecular Recognition, Columbia University College of Physicians and Surgeons
Harel Weinstein: Weill Medical College of Cornell University
Scott C. Blanchard: Weill Medical College of Cornell University
Jonathan A. Javitch: Center for Molecular Recognition, Columbia University College of Physicians and Surgeons

Nature, 2011, vol. 474, issue 7349, 109-113

Abstract: An open gate to neurotransmitters Neurotransmitters are removed from the synapse by neurotransmitter/Na+ symporters (NSSs) in a reuptake process driven by the Na+ gradient. Zhao et al. examined the coupling of substrate binding to structural transitions in the prokaryotic NSS homologue LeuT. Using single-molecule fluorescence resonance energy transfer, functional experiments and computational studies, they find that LeuT facilitates intracellular gate opening and substrate release at the intracellular face of the protein.

Date: 2011
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DOI: 10.1038/nature09971

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