Glutamate induces de novo growth of functional spines in developing cortex

Hyung-Bae Kwon and Bernardo L. Sabatini ()
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Hyung-Bae Kwon: Howard Hughes Medical Institute, Harvard Medical School
Bernardo L. Sabatini: Howard Hughes Medical Institute, Harvard Medical School

Nature, 2011, vol. 474, issue 7349, 100-104

Abstract: Early neural development It is known that dendritic spines are formed de novo in the developing brain in response to learning and sensory experiences, but the biochemistry underlying this process remains unknown. Hyung-Bae Kwon and Bernardo Sabatini combine single-spine imaging and light-controlled neurotransmitter release (uncaging) to demonstrate new spine growth in response to glutamate at specific locations along a dendrite. The process requires functional NMDA receptors and PKA signalling, with new spines rapidly maturing and responding to presynaptic signals. These data suggest that neural activity can rapidly initiate new connections in a location-specific manner along dendrites.

Date: 2011
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DOI: 10.1038/nature09986

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