Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

Momoko Maekawa, Kei Yamaguchi, Tomonori Nakamura, Ran Shibukawa, Ikumi Kodanaka, Tomoko Ichisaka, Yoshifumi Kawamura, Hiromi Mochizuki, Naoki Goshima () and Shinya Yamanaka ()
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Momoko Maekawa: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
Kei Yamaguchi: Japan Biological Informatics Consortium, Tokyo 135-0064, Japan
Tomonori Nakamura: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
Ran Shibukawa: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
Ikumi Kodanaka: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
Tomoko Ichisaka: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
Yoshifumi Kawamura: Japan Biological Informatics Consortium, Tokyo 135-0064, Japan
Hiromi Mochizuki: Japan Biological Informatics Consortium, Tokyo 135-0064, Japan
Naoki Goshima: Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan
Shinya Yamanaka: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

Nature, 2011, vol. 474, issue 7350, 225-229

Abstract: Glis1 substitutes for c-Myc in stem-cell generation Reprogramming of differentiated somatic cells to induced pluripotent stem (iPS) cells by exogenous expression of key transcription factors (Oct4, Sox2, Klf4 and c-Myc) has potential therapeutic applications. c-Myc enhances the efficiency of reprogramming, but the safety of using this oncogene has long been a concern. Now, Shinya Yamanaka and colleagues have found that the transcription factor Glis1 effectively and specifically promotes reprogramming of human and mouse somatic cells to iPS cells. Glis1 is highly enriched in unfertilized eggs and one-cell-stage embryos, and might be a link between reprogramming during iPS cell generation and after nuclear transfer into zygotes.

Date: 2011
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DOI: 10.1038/nature10106

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