A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

Wilson K. Clements, Albert D. Kim, Karen G. Ong, John C. Moore, Nathan D. Lawson and David Traver ()
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Wilson K. Clements: University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA
Albert D. Kim: University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA
Karen G. Ong: University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA
John C. Moore: Program in Gene Function and Expression, University of Massachusetts Medical School
Nathan D. Lawson: Program in Gene Function and Expression, University of Massachusetts Medical School
David Traver: University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA

Nature, 2011, vol. 474, issue 7350, 220-224

Abstract: Novel pathway specifies haematopoietic stem cells The identification of factors that regulate the earliest steps of haematopoietic stem cell (HSC) formation is of potential therapeutic relevance. Clements et al. have identified a new genetic regulatory network that is required for HSC specification in vertebrates. They report that non-canonical Wnt signalling by Wnt16 is required for somitic expression of Notch ligands deltaC and deltaD, which in turn leads to HSC specification.

Date: 2011
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DOI: 10.1038/nature10107

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