A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Siwanon Jirawatnotai, Yiduo Hu, Wojciech Michowski, Joshua E. Elias, Lisa Becks, Frederic Bienvenu, Agnieszka Zagozdzon, Tapasree Goswami, Yaoyu E. Wang, Alan B. Clark, Thomas A. Kunkel, Tanja van Harn, Bing Xia, Mick Correll, John Quackenbush, David M. Livingston, Steven P. Gygi and Piotr Sicinski ()
Additional contact information
Siwanon Jirawatnotai: Dana-Farber Cancer Institute, Harvard Medical School
Yiduo Hu: Dana-Farber Cancer Institute, Harvard Medical School
Wojciech Michowski: Dana-Farber Cancer Institute, Harvard Medical School
Joshua E. Elias: Harvard Medical School
Lisa Becks: Dana-Farber Cancer Institute, Harvard Medical School
Frederic Bienvenu: Dana-Farber Cancer Institute, Harvard Medical School
Agnieszka Zagozdzon: Dana-Farber Cancer Institute, Harvard Medical School
Tapasree Goswami: Harvard Medical School
Yaoyu E. Wang: Center for Cancer Computational Biology, Dana-Farber Cancer Institute
Alan B. Clark: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health
Thomas A. Kunkel: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health
Tanja van Harn: Dana-Farber Cancer Institute, Harvard Medical School
Bing Xia: The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School
Mick Correll: Center for Cancer Computational Biology, Dana-Farber Cancer Institute
John Quackenbush: Center for Cancer Computational Biology, Dana-Farber Cancer Institute
David M. Livingston: Dana-Farber Cancer Institute, Harvard Medical School
Steven P. Gygi: Harvard Medical School
Piotr Sicinski: Dana-Farber Cancer Institute, Harvard Medical School

Nature, 2011, vol. 474, issue 7350, 230-234

Abstract: Cyclin D1 role in DNA repair Cyclin D1 has a crucial role in the cell cycle and is often overexpressed in cancer. Piotr Sicinski and colleagues report an unexpected function for cyclin D1 in DNA repair that is independent of its known CDK-dependent role. Cyclin D1 is recruited to sites of DNA damage and binds to RAD51, a key DNA recombinase that drives the homologous recombination process. This function for cyclin D1 also operates in retinoblastoma protein (pRB)-negative human cancer, suggesting that targeting cyclin D1 may be beneficial in this condition.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature10155 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:474:y:2011:i:7350:d:10.1038_nature10155

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10155

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().