In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

Joji Fujisaki (), Juwell Wu, Alicia L. Carlson, Lev Silberstein, Prabhakar Putheti, Rafael Larocca, Wenda Gao, Toshiki I. Saito, Cristina Lo Celso, Hitoshi Tsuyuzaki, Tatsuyuki Sato, Daniel Côté, Megan Sykes, Terry B. Strom, David T. Scadden and Charles P. Lin ()
Additional contact information
Joji Fujisaki: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Juwell Wu: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Alicia L. Carlson: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Lev Silberstein: Harvard Stem Cell Institute, 42 Church Street
Prabhakar Putheti: Beth Israel Deaconess Medical Center
Rafael Larocca: Beth Israel Deaconess Medical Center
Wenda Gao: Beth Israel Deaconess Medical Center
Toshiki I. Saito: Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg.149-5102 13th Street, Boston, Massachusetts 02129, USA
Cristina Lo Celso: Harvard Stem Cell Institute, 42 Church Street
Hitoshi Tsuyuzaki: Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Tatsuyuki Sato: Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Daniel Côté: Génie Physique et Optique & Centre de Recherche Université Laval Robert-Giffard, Québec City, Québec G1J 2G3, Canada
Megan Sykes: Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg.149-5102 13th Street, Boston, Massachusetts 02129, USA
Terry B. Strom: Beth Israel Deaconess Medical Center
David T. Scadden: Harvard Stem Cell Institute, 42 Church Street
Charles P. Lin: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA

Nature, 2011, vol. 474, issue 7350, 216-219

Abstract: A privileged position A new study identifies the bone marrow haematopoietic stem cell (HSC) niche — a specialized microenvironment where stem cells reside — as an immune privileged site. This property is known to exist in the testis, ovary and hair follicle but has not been universally demonstrated in all stem cell niches. High-resolution in vivo imaging shows the accumulation of regulatory T cells in the HSC niche, enabling transplanted allo-HSCs to escape from allogeneic rejection. As well as supporting stem-cell function, the niche may provide a relative sanctuary from immune attack that could extend to malignant cells in some instances.

Date: 2011
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DOI: 10.1038/nature10160

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