A genetically humanized mouse model for hepatitis C virus infection

Marcus Dorner, Joshua A. Horwitz, Justin B. Robbins, Walter T. Barry, Qian Feng, Kathy Mu, Christopher T. Jones, John W. Schoggins, Maria Teresa Catanese, Dennis R. Burton, Mansun Law, Charles M. Rice and Alexander Ploss ()
Additional contact information
Marcus Dorner: Center for the Study of Hepatitis C, The Rockefeller University
Joshua A. Horwitz: Center for the Study of Hepatitis C, The Rockefeller University
Justin B. Robbins: The Scripps Research Institute
Walter T. Barry: Center for the Study of Hepatitis C, The Rockefeller University
Qian Feng: Center for the Study of Hepatitis C, The Rockefeller University
Kathy Mu: Center for the Study of Hepatitis C, The Rockefeller University
Christopher T. Jones: Center for the Study of Hepatitis C, The Rockefeller University
John W. Schoggins: Center for the Study of Hepatitis C, The Rockefeller University
Maria Teresa Catanese: Center for the Study of Hepatitis C, The Rockefeller University
Dennis R. Burton: The Scripps Research Institute
Mansun Law: The Scripps Research Institute
Charles M. Rice: Center for the Study of Hepatitis C, The Rockefeller University
Alexander Ploss: Center for the Study of Hepatitis C, The Rockefeller University

Nature, 2011, vol. 474, issue 7350, 208-211

Abstract: A mouse model for hepatitis C infection The development of therapies for hepatitis C virus (HCV) infection has been hampered by the lack of a small-animal model of the disease. Now Alexander Ploss and colleagues describe the first immunocompetent rodent model for hepatitis C virus infection, using adenoviruses expressing four human factors to enable entry of HCV into mouse cells. These vectors were then used to transduce the livers of mice, which then became susceptible to HCV infection. Although the model does not enable a complete virus replication cycle, it should be useful for the evaluation of HCV vaccines and entry inhibitors.

Date: 2011
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DOI: 10.1038/nature10168

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