COP1 is a tumour suppressor that causes degradation of ETS transcription factors

Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen O’Rourke, Jinfeng Liu, Lilian Phu, Rajesh Vij, Ronald Ferrando, Suzana S. Couto, Sankar Mohan, Ajay Pandita, Jo-Anne Hongo, David Arnott, Ingrid E. Wertz, Wei-Qiang Gao, Dorothy M. French and Vishva M. Dixit ()
Additional contact information
Alberto C. Vitari: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kevin G. Leong: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kim Newton: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Cindy Yee: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Karen O’Rourke: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jinfeng Liu: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Lilian Phu: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Rajesh Vij: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ronald Ferrando: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Suzana S. Couto: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Sankar Mohan: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ajay Pandita: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jo-Anne Hongo: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
David Arnott: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ingrid E. Wertz: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Wei-Qiang Gao: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Dorothy M. French: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Vishva M. Dixit: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2011, vol. 474, issue 7351, 403-406

Abstract: COP1 in prostate cancer Translocations in transcription factors in the E26 transformation-specific (ETS) family are common in prostate cancer. Dixit and colleagues now find that the ubiquitin ligase COP1 normally ubiquitinates certain ETS factors, leading to their degradation. The proteins encoded by the translocations, however, lack the COP1 signal and thus evade degradation. COP1 acts as a tumour suppressor, and its deletion causes neoplasias in the mouse prostate by increasing ETS factor levels. The authors also show that the loss of COP1, like ETS translocations, can lead to upregulation of ETS factors in human prostate cancers.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature10005 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10005

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10005

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().